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Search Results for " cysteine protease "

46

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10924	Cysteine protease inhibitor-2	Cysteine Protease	Proteases/Proteasome
	Cysteine protease inhibitor-2 是半胱氨酸蛋白酶抑制剂。
T10925	Cysteine Protease inhibitor	Others	Others
	Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease
T10925L	Cysteine Protease inhibitor hydrochloride Cysteine Protease inhibitor hydrochloride (921625-62-9 free base)	Others	Others
	Cysteine Protease inhibitor hydrochloride 是一种半胱氨酸蛋白酶(cysteine protease)抑制剂。
T7451	2-Cyanopyrimidine 2-氰基嘧啶,2-cyano-Pyrimidine	Cysteine Protease	Proteases/Proteasome
	2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) 是半胱氨酸蛋白酶组织蛋白酶 K (cysteine protease cathepsin K) 的非选择性抑制剂(IC50:170 nM)。它能够用于骨质疏松症的研究。
T79277	Cysteine protease inhibitor-3	Parasite	Microbiology/Virology
	Cysteine protease Inhibitor-3 (Compound 15) 是抗疟作用的半胱氨酸蛋白酶抑制剂，能够有效地抑制 Pf3D7、PfW2、PfFP2 和 PfFP3，其 IC50 分别为 0.74 μM、1.05 μM、3.5 μM 和 4.9 μM。该化合物对药物敏感性和耐药性寄生虫均有效。
T6037	E-64 Proteinase inhibitor E 64,E 64,E64	Cysteine Protease; Antibacterial; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	E-64 (Proteinase inhibitor E 64)是一种不可逆的半胱氨酸蛋白酶抑制剂，抑制papain 的IC50为 9 nM。
T5211	NSC 185058 NSC185058	Cysteine Protease; Autophagy	Autophagy; Proteases/Proteasome
	NSC 185058 是一种半胱氨酸蛋白酶 ATG4B 抑制剂，可抑制自噬。
T2470	MDL-28170 Calpain Inhibitor III	Cysteine Protease; Proteasome	Proteases/Proteasome; Ubiquitination
	MDL-28170 (Calpain Inhibitor III) 是一种选择性的、有效的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可在全身给药后迅速穿过血脑屏障。它还能阻断γ-secretase。
T6738	Z-FA-FMK	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂，可抑制冠状病毒蛋白酶3CL，Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶，也可以抑制效应半胱天冬酶。
T20626	Esomeprazole	Proton pump; Cysteine Protease	Membrane transporter/Ion channel; Proteases/Proteasome
	Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。
T15641	K777 APC-3316	P450; Cysteine Protease; CCR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	K777 是有效的，具有口服活性的，不可逆的半胱氨酸蛋白酶 (cysteine protease) 抑制剂。K777是有效的 CYP3A4 抑制剂(IC50= 60 nM)。K777也是选择性的 CCR4 拮抗剂，显示出强的趋化性抑制作用。K777 对 Cruzain（克鲁斯锥虫的主要半胱氨酸蛋白酶）和组织蛋白酶 B 和 L 具有不可逆的抑制作用。K777 通过靶向组织蛋白酶介导的细胞进入，显示出广谱的抗病毒作用。K777 抑制 EBOV 和 SARS-CoV 病毒的进入，IC50 值分别为 0.87 nM 和 0.68 nM。
T16809	Rupintrivir AG-7088,AG7088,Rupintrivirvr	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Rupintrivirvr (AG7088) 是一种选择性鼻病毒 (HRV) 3C 半胱氨酸蛋白酶的拟肽抑制剂，具有抗病毒活性和免疫调节活性。Rupintrivirvr 抑制 EV71 和 EV-D68 复制，可用于研究病毒感染。
T6040	Aloxistatin E64d,Loxistatin,阿洛司他丁,E64c ethyl ester	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Aloxistatin (E64d) 是一种不可逆的、可透过膜的溶酶体和细胞溶质半胱氨酸蛋白酶抑制剂，能够抑制完整血小板中的钙蛋白酶活性。它是一种半胱氨酸蛋白酶抑制剂，具有血小板聚集抑制活性。
T6573	E 64c 阿洛司他丁酸,NSC 694279,EP 475,Loxistatin Acid	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	E 64c (EP 475) 是一种不可逆且可透过膜的半胱氨酸蛋白酶抑制剂，是 E-64 的衍生物。它也是钙离子激活中性蛋白酶抑制剂和组织蛋白酶 C 弱不可逆抑制剂，可抑制 MERS-CoV。
T77525	EN450	NF-κB	NF-κB
	EN450 是一种针对的 NF-κB 的半胱氨酸反应性共价分子胶降解剂，具有抗增殖活性和潜在的抗癌活性，通过依赖Cullin E3 连接酶和蛋白酶发挥作用，可用于研究白血病。
T9458	PF-00835231	SARS-CoV	Microbiology/Virology
	PF-00835231 是一种 CoV-2 半胱氨酸 3C 样蛋白酶抑制剂，对 SARS CoV-2 和 SARS CoV-1 3CLpro 的 IC50 分别为 0.27 nM 和 4 nM。它用于抗 SARS-CoV-2/COVID-19 的研究。
T36352	Suc-Leu-Tyr-AMC
	Suc-Leu-Tyr-AMC 是钙蛋白酶 I 和 II 以及木瓜蛋白酶（另一种半胱氨酸蛋白酶）的荧光底物，用于测量 20S 蛋白酶体的糜蛋白酶样肽酶活性（Ex-max：360 nm；Em-max：460 nm）。Suc-Leu-Tyr-AMC 也能被大肠杆菌的 Ti 蛋白酶裂解。
T3161L	BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base)	BACE	Neuroscience
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶，属于蛋白酶家族，由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。
T17026	Tecovirimat ST-246,特考韦瑞	Cysteine Protease	Proteases/Proteasome
	Tecovirimat 是一种核心蛋白半胱氨酸蛋白酶抑制剂，可能用于治疗天花感染。Tecovirimat 是一种新型抗病毒药物，对多种正痘病毒具有有效和选择性的活性（EC50：约 10 nM）。通过靶向病毒 p37 蛋白直系同源物来抑制正痘病毒的排出。迄今为止，Tecovirimat 已在所有小动物和非人类灵长类动物预防和治疗痘病毒引起的疾病模型中显示出功效。
T27730	KGP94 KGP-94,KGP 94	Cysteine Protease	Proteases/Proteasome
	KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。
T24564	NVP-ABJ688 ABJ-688,ABJ 688,ABJ688
	NVP-ABJ688 is the cysteine protease cathepsin K inhibitor.
T12819	S130	Cysteine Protease	Proteases/Proteasome
	S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
T11846	LHVS	Cysteine Protease	Proteases/Proteasome
	LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.
T69182	APC-3316 hydrochloride
	APC-3316 hydrochloride is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.
T69183	APC-3316 tosylate
	APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.
T23596	A-933548 A933548,A 933548
	A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
T23598	A-953227 A 953227,A953227
	A-953227 is a highly effective and selective inhibitor of calpain. A-953227 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
T6564L	Leupeptin Leupeptin Ac-LL,NK-381
	Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine p
T14555	BI-1230	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between other serine/cysteine proteases. Additionally, BI-1230 exhibits favorable pharmacokinetic (PK) properties[1].
T61364	LmCPB-IN-1
	LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1].
T38931	Calpain Inhibitor-1
	Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM.
T71487	WRR-483
	WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner...
T69297	Leupeptin HCl
	Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. Leupeptin is a competitive transition state inhibitor and its inhibition may be relieved by...
T80542	Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK
	Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK)为半胱氨酸蛋白酶抑制剂，可抑制SARS感染，并能保护小鼠免遭T. crassiceps侵害。
T80052	Cathepsin B
	Cathepsin B为一种半胱氨酸蛋白酶，涉及多种程序性细胞死亡（包括细胞凋亡、焦亡、铁亡、坏死亡及自噬性细胞死亡）。
T80739	Z-FG-NHO-BzOME
	Z-FG-NHO-BzOME 是一种选择性半胱氨酸蛋白酶抑制剂，主要作用于组织蛋白酶 B、组织蛋白酶 L、组织蛋白酶 S 及木瓜蛋白酶。
T80722	Z-LVG
	Z-LVG为一种不可逆半胱氨酸蛋白酶抑制剂，作为半胱抑素C的三肽衍生物，其可抑制病毒复制，应用于病毒相关疾病研究。
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].
T63760	3CPLro-IN-2
	3CPLro-IN-2 是有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 1.55 μM, Ki: 6.09 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是病毒复制中不可或缺的蛋白质，是有潜力的对抗 COVID-19 的药物靶点。
T64159	Cathepsin K inhibitor 2
	Cathepsin K inhibitor 2 是一种 cathepsin K 的有效抑制剂。其中 Cathepsin K (Cat K) 是一种半胱氨酸蛋白酶，在 CTSK 基因调控下表达，与骨质疏松症密切相关，能够水解胶原蛋白。Cathepsin K inhibitor 2 对骨关节炎表现出研究潜力。
T62479	3CPLro-IN-1
	3CPLro-IN-1 (compound A17) 是一种有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 5.65 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是一种病毒复制中不可或缺的蛋白质，是一种有吸引力的、对抗 COVID-19 的药物靶点。
T75394	Picornain 3C
	Picornain 3C为发现于小核糖核酸病毒中的蛋白酶，具有切割非末端序列肽键的能力。该酶是丝氨酸肽酶胰凝乳蛋白酶与半胱氨酸肽酶木瓜蛋白酶中间产物，展示内肽酶活性。特别地，Picornain 3C选择性切割脊髓灰质炎病毒多聚蛋白中的Gln-Gly键，以及在其他小核糖核酸病毒中，Gln被Glu替代，Gly被Ser或Thr替代的情况下亦能切割。
T78119	Z-L(D-Val)G-CHN2	HSV	Microbiology/Virology
	Z-L(D-Val)G-CHN2（即Z-LVG-CHN2）是半胱氨酸蛋白酶抑制剂的异构体，作为一种三肽衍生物，模仿了人体半胱氨酸蛋白酶结合中心的部分结构。它可以抑制HSV，并且能有效阻断SARS-COV-2的3CL pro蛋白酶，从而抑制病毒活性（EC50=190 nM），但对脊髓灰质炎病毒复制无显著作用。
T78138	SIC5-6	Others	Others
	SIC5-6为一强效Separase抑制剂，此酶为大型半胱氨酸蛋白酶，关键参与有丝分裂与减数分裂中染色体分离，DNA损伤修复，中心体分离与复制，以及纺锤体稳定与伸长。Separase在众多实体瘤高表达，成为潜在的化疗靶标。
T36668	Geranylgeranoic Acid
	Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also...
T35802	ML-345
	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de...

化合物

Cysteine protease inhibitor-2

Cat.No: T10924

Target: Cysteine Protease

Cysteine Protease inhibitor

Cat.No: T10925

Target: Others

Cysteine Protease inhibitor hydrochloride

Cat.No: T10925L

Synonym: Cysteine Protease inhibitor hydrochloride (921625-62-9 free base)

Target: Others

2-Cyanopyrimidine

Cat.No: T7451

Synonym: 2-氰基嘧啶,2-cyano-Pyrimidine

Target: Cysteine Protease

Cysteine protease inhibitor-3

Cat.No: T79277

Target: Parasite

Cat.No: T6037

Synonym: Proteinase inhibitor E 64,E 64,E64

Target: Cysteine Protease, Antibacterial, Autophagy

Cat.No: T5211

Synonym: NSC185058

Target: Cysteine Protease, Autophagy

Cat.No: T2470

Synonym: Calpain Inhibitor III

Target: Cysteine Protease, Proteasome

Cat.No: T6738

Target: SARS-CoV, Cysteine Protease

Cat.No: T20626

Target: Proton pump, Cysteine Protease

Cat.No: T15641

Synonym: APC-3316

Target: P450, Cysteine Protease, CCR

Cat.No: T16809

Synonym: AG-7088,AG7088,Rupintrivirvr

Target: Virus Protease, Antiviral

Cat.No: T6040

Synonym: E64d,Loxistatin,阿洛司他丁,E64c ethyl ester

Target: SARS-CoV, Cysteine Protease

Cat.No: T6573

Synonym: 阿洛司他丁酸,NSC 694279,EP 475,Loxistatin Acid

Target: SARS-CoV, Cysteine Protease

Cat.No: T77525

Target: NF-κB

Cat.No: T9458

Target: SARS-CoV

Suc-Leu-Tyr-AMC

Cat.No: T36352

BACE-IN-1 acetate

Cat.No: T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Cat.No: T17026

Synonym: ST-246,特考韦瑞

Target: Cysteine Protease

Cat.No: T27730

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

Cat.No: T24564

Synonym: ABJ-688,ABJ 688,ABJ688

Cat.No: T12819

Target: Cysteine Protease

Cat.No: T11846

Target: Cysteine Protease

APC-3316 hydrochloride

Cat.No: T69182

APC-3316 tosylate

Cat.No: T69183

Cat.No: T23596

Synonym: A933548,A 933548

Cat.No: T23598

Synonym: A 953227,A953227

Cat.No: T6564L

Synonym: Leupeptin Ac-LL,NK-381

Cat.No: T14555

Target: HCV Protease

Cat.No: T61364

Calpain Inhibitor-1

Cat.No: T38931

Cat.No: T71487

Cat.No: T69297

Z-Leu-Leu-Leu-fluoromethyl ketone

Cat.No: T80542

Synonym: Z-LLL-FMK

Cat.No: T80052

Cat.No: T80739

Cat.No: T80722

SARS-CoV-2 3CLpro-IN-1

Cat.No: T63537

Cat.No: T63760

Cathepsin K inhibitor 2

Cat.No: T64159

Cat.No: T62479

Cat.No: T75394

Z-L(D-Val)G-CHN2

Cat.No: T78119

Target: HSV

Cat.No: T78138

Target: Others

Geranylgeranoic Acid

Cat.No: T36668

Cat.No: T35802

Cat. No.	Product Name	Target	Signaling Pathways
T19503	Papain	Others; Cysteine Protease	Others; Proteases/Proteasome
	Papain 是一种半胱氨酸蛋白酶，是肽酶 C1 家族中一员，在食品、医药、化妆品、纺织等具有广泛的应用。
T2768	Saikosaponin A 柴胡皂苷A,柴胡皂苷 A	NF-κB; Antibacterial; Liver X Receptor	Metabolism; Microbiology/Virology; NF-κB
	Saikosaponin A 是银柴胡中的主要活性成分，有抗炎活性，可上调 LXRα的表达。

天然产物

Cat.No: T19503

Target: Others, Cysteine Protease

Cat.No: T2768

Synonym: 柴胡皂苷A,柴胡皂苷 A

Target: NF-κB, Antibacterial, Liver X Receptor

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